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Rabbit Anti-LAMTOR5 Recombinant Antibody (D4V4S) (CBMAB-CP0909-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D4V4S
Antibody Isotype
IgG
Application
WB, IP, IHC-P

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu55 of human LAMTOR5/HBXIP protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Late Endosomal/Lysosomal Adaptor, Mapk And Mtor Activator 5
Entrez Gene ID
Human10542
Mouse68576
Rat295357
Monkey701645
UniProt ID
HumanO43504
MouseQ9D1L9
RatD3ZF11
MonkeyA0A2K5VZZ0
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.
Biological Process
Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of RNA polymerase II regulatory region sequence-specific DNA bindingManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of TORC1 signalingManual Assertion Based On ExperimentIBA:GO_Central
Protein localization to lysosomeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell sizeManual Assertion Based On ExperimentIMP:UniProtKB
Response to virusManual Assertion Based On ExperimentTAS:ProtInc
Viral genome replicationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Lysosome
Cytoplasm, cytosol
More Infomation

Chen, G., Wang, K., Li, G., Wang, L., Xiao, Y., & Chen, B. (2022). Long noncoding RNA LAMTOR5-AS1 interference affects microRNA-506-3p/E2F6-mediated behavior of non-small cell lung cancer cells. Oncology research, 28(9), 945.

Yang, B., Wang, Z., Deng, Y., Xiao, L., & Zhang, K. (2022). LncRNA LAMTOR5‐AS1 sponges miR‐210‐3p and regulates cervical cancer progression. Journal of Obstetrics and Gynaecology Research, 48(12), 3171-3178.

Qin, Y., Ni, P., Zhang, Q., Wang, X., Du, X., Yin, Z., ... & Chen, L. (2022). Hbxip (Lamtor5) is essential for embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1. bioRxiv, 2022-01.

Pu, Y., Tan, Y., Zang, C., Zhao, F., Cai, C., Kong, L., ... & Huang, D. (2021). LAMTOR5-AS1 regulates chemotherapy-induced oxidative stress by controlling the expression level and transcriptional activity of NRF2 in osteosarcoma cells. Cell Death & Disease, 12(12), 1125.

Zaniani, N. R., Oroujalian, A., Valipour, A., & Peymani, M. (2021). LAMTOR5 expression level is a biomarker for colorectal cancer and lncRNA LAMTOR5-AS1 predicting miRNA sponging effect. Molecular Biology Reports, 48(8), 6093-6101.

Zhang, W., Zhuang, N., Liu, X., He, L., He, Y., Mahinthichaichan, P., ... & Shi, L. (2020). The metabolic regulator Lamtor5 suppresses inflammatory signaling via regulating mTOR-mediated TLR4 degradation. Cellular & molecular immunology, 17(10), 1063-1076.

Fang, R., Xu, F., Shi, H., Wu, Y., Cao, C., Li, H., ... & Ye, L. (2020). LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity. Oncogene, 39(11), 2290-2304.

Yang, Q. C., Wu, C. C., Cao, L. Y., Xiao, Y., Li, H., Liu, B., & Sun, Z. J. (2019). Increased expression of LAMTOR5 predicts poor prognosis and is associated with lymph node metastasis of head and neck squamous cell carcinoma. International Journal of Medical Sciences, 16(6), 783.

Zhou, J., Li, Y., Li, D., Liu, Z., & Zhang, J. (2019). Oncoprotein LAMTOR5 activates GLUT1 via upregulating NF-κB in liver cancer. Open Medicine, 14(1), 264-270.

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For research use only. Not intended for any clinical use.

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