LIMD1

LIMD1 (LIM Domains Containing 1) is a protein coding gene. Among its related pathways are Cytoskeletal Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology annotations related to this gene include transcription corepressor activity. An important paralog of this gene is WTIP.

Full Name

LIM Domains Containing 1

Function

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation.

Biological Process

Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Gene silencing by miRNAManual Assertion Based On ExperimentIMP:MGI
Negative regulation of canonical Wnt signaling pathwayISS:UniProtKB
Negative regulation of hippo signalingManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of osteoblast differentiationISS:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Osteoblast developmentISS:UniProtKB
P-body assemblyManual Assertion Based On ExperimentIMP:MGI
PhosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene silencing by miRNAManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell shapeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Response to hypoxiaManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Cytoplasm, P-body
Cell junction, adherens junction
Cell junction, focal adhesion
Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down-regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis.

PTM

Phosphorylated during mitosis.