LPAR1

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq]

lysophosphatidic acid receptor 1

Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040).
Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040).
Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040).
Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925).
Signaling mediates activation of down-stream MAP kinases (By similarity).
Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040).
Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040).
Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity).
Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258).
Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).

Activation of phospholipase C activityManual Assertion Based On ExperimentIDA:UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayISS:UniProtKB
Cell chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of neuron projection developmentISS:UniProtKB
NeurogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of MAPK cascadeISS:UniProtKB
Positive regulation of Rho protein signal transductionISS:UniProtKB
Positive regulation of stress fiber assemblyISS:UniProtKB
Regulation of cell shapeISS:UniProtKB
Regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cell surface
Cell membrane
Endosome
Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment.

Extracellular: 1-50
Helical: 51-75
Cytoplasmic: 76-83
Helical: 84-107
Extracellular: 108-121
Helical: 122-144
Cytoplasmic: 145-163
Helical: 164-184
Extracellular: 185-204
Helical: 205-225
Cytoplasmic: 226-255
Helical: 256-280
Extracellular: 281-294
Helical: 295-315
Cytoplasmic: 316-364

N-glycosylated.