MCTS1

MCTS1 (MCTS1, Re-Initiation And Release Factor) is a Protein Coding gene. Diseases associated with MCTS1 include Fuchs' Endothelial Dystrophy. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity.

Full Name

MCTS1, RE-INITIATION AND RELEASE FACTOR

Function

Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

Biological Process

Cell cycle Source: UniProtKB-KW
Cellular response to DNA damage stimulus Source: UniProtKB-KW
Formation of translation preinitiation complex Source: UniProtKB
IRES-dependent viral translational initiation Source: UniProtKB
Positive regulation of cell population proliferation Source: ProtInc
Regulation of growth Source: UniProtKB-KW
Ribosome disassembly Source: UniProtKB

Cellular Location

Cytoplasm
Note: Nuclear relocalization after DNA damage.

PTM

Phosphorylation is critical for stabilization and promotion of cell proliferation.