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Mouse Anti-MCTS1 (AA 1-181 ) Recombinant Antibody (CBFYM-1927) (CBMAB-M2101-FY)

This product is mouse antibody that recognizes MCTS1. The antibody CBFYM-1927 can be used for immunoassay techniques such as: WB, IHC, IHC-P.
See all MCTS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1927
Antibody Isotype
IgG2a
Application
WB, IHC, IHC-P

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-181 of human MCTS1 (NP_054779) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-181

Target

Full Name
MCTS1, RE-INITIATION AND RELEASE FACTOR
Introduction
MCTS1 is a Protein Coding gene. Diseases associated with MCTS1 include Fuchs' Endothelial Dystrophy. Gene Ontology annotations related to this gene include RNA binding and translation initiation factor activity.
Entrez Gene ID
28985
UniProt ID
Q9ULC4
Alternative Names
MCTS1, Re-Initiation And Release Factor; Malignant T-Cell Amplified Sequence 1; Multiple Copies In T-Cell Lymphoma-1; Multiple Copies T-Cell Malignancies; MCT-1; MCT1; Malignant T-Cell-Amplified Sequence 1
Function
Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Biological Process
Cell cycle Source: UniProtKB-KW
Cellular response to DNA damage stimulus Source: UniProtKB-KW
Formation of translation preinitiation complex Source: UniProtKB
IRES-dependent viral translational initiation Source: UniProtKB
Positive regulation of cell population proliferation Source: ProtInc
Regulation of growth Source: UniProtKB-KW
Ribosome disassembly Source: UniProtKB
Cellular Location
Cytoplasm
Note: Nuclear relocalization after DNA damage.
PTM
Phosphorylation is critical for stabilization and promotion of cell proliferation.

Bohlen, J., Zhou, Q., Philippot, Q., Ogishi, M., Rinchai, D., Nieminen, T., ... & Casanova, J. L. (2023). Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria. Cell, 186(23), 5114-5134.

Ma, B., Wei, X., Zhou, S., & Yang, M. (2023). MCTS1 enhances the proliferation of laryngeal squamous cell carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination. Biochemical and Biophysical Research Communications, 678, 128-134.

Deng, M., Xiong, C., He, Z. K., Bin, Q., Song, J. Z., Li, W., & Qin, J. (2022). MCTS1 as a novel prognostic biomarker and its correlation with immune infiltrates in breast cancer. Frontiers in Genetics, 13, 825901.

Yang, M., Ma, B., & Liu, X. (2022). MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability. Clinical and Experimental Pharmacology and Physiology, 49(6), 652-660.

Huang, Z., Su, Q., Li, W., Ren, H., Huang, H., & Wang, A. (2021). MCTS1 promotes invasion and metastasis of oral cancer by modifying the EMT process. Annals of Translational Medicine, 9(12).

Gao, C., Dong, R., Li, Y., Liang, J., & Tian, H. (2021). MCTS1 promotes the development of lung adenocarcinoma by regulating E2F1 expression. Oncology Letters, 22(1), 1-10.

Yu, S. E. (2021). The role of the MCTS1 and DENR proteins in regulating the mechanisms associated with malignant cell transformation. Acta Naturae (англоязычная версия), 13(2), 98-105.

Green, K. M., Miller, S. L., Malik, I., & Todd, P. K. (2021). DENR/MCTS1 knockdown modulates repeat-associated non-AUG translation. bioRxiv, 2021-08.

Tian, C., Zeng, S., & Luo, J. (2020). MCTS1 directly binds to TWF1 and synergistically modulate Cyclin D1 and C-Myc translation in luminal A/B breast cancer cells. OncoTargets and therapy, 5353-5361.

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For research use only. Not intended for any clinical use.

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