MPP5

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001 [PubMed 11311936]). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611).

Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity).

Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317).

Required during embryonic and postnatal retinal development (By similarity).

Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity).

Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity).

Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity).

May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity).

Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189).

Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).

Required for the normal polarized localization of the vesicular marker STX4 (By similarity).

Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity).

Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).

(Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity.

Central nervous system neuron development Source: UniProtKB
Cerebral cortex development Source: UniProtKB
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Establishment or maintenance of polarity of embryonic epithelium Source: GO_Central
Gene expression Source: Ensembl
Generation of neurons Source: GO_Central
Morphogenesis of an epithelial sheet Source: UniProtKB
Myelin assembly Source: Ensembl
Peripheral nervous system myelin maintenance Source: Ensembl
Protein localization to myelin sheath abaxonal region Source: Ensembl
Protein localization to plasma membrane Source: GO_Central
Regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB

Golgi apparatus
Plasma membrane
Cell membrane
Apical cell membrane
Other locations
Endomembrane system
tight junction
adherens junction
axon
Perikaryon
Note: Localized to the tight junctions of epithelial cells (By similarity). Localized to the Golgi apparatus in T lymphocytes (PubMed:21479189). Localized to a subset of intracellular vesicles (By similarity). Localized to the Purkinje cell body and axon (By similarity). Localized to intercellular junctions in vascular endothelial cells (PubMed:27466317). Localized to Schmidt-Lanterman incisures, the adaxonal domain, and the inner part of paranodal loops in myelinating Schwann cells of the sciatic nerve (By similarity). Localized to apical membrane domains of the outer limiting membrane (OLM) junctions in the retina (By similarity). Colocalizes with CRB1 at the OLM, apical to the adherens junction (PubMed:15914641). Colocalizes with MPP1 in the retina at the OLM (PubMed:17584769). Colocalizes with MPP3 to the subapical region of adherens junctions in the retina OLM (PubMed:16519681).
Golgi apparatus
Other locations
Endoplasmic reticulum-Golgi intermediate compartment
Note: (Microbial infection) Following infection by human SARS coronavirus, partially localized at the site of viral replication; the endoplasmic reticulum-Golgi intermediate compartment, reducing its levels at cell-cell contacts which results in delayed formation of tight junctions and affects establishment of cell polarity.