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Mouse Anti-MPP5 Recombinant Antibody (CBFYM-0711) (CBMAB-M0853-FY)

This product is mouse antibody that recognizes MPP5. The antibody CBFYM-0711 can be used for immunoassay techniques such as: ELISA, WB.
See all MPP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0711
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Introduction
This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells, and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
64398
UniProt ID
Q8N3R9
Alternative Names
Membrane Palmitoylated Protein 5; Membrane Protein, Palmitoylated 5 (MAGUK P55 Subfamily Member 5); Protein Associated With Lin-7 1; Stardust; Protein Associated With Lin Seven 1; Membrane Protein, Palmitoylated 5; MAGUK P55 Subfamily Member 5; PALS1
Function
Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611).

Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity).

Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317).

Required during embryonic and postnatal retinal development (By similarity).

Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity).

Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity).

Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity).

May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity).

Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189).

Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).

Required for the normal polarized localization of the vesicular marker STX4 (By similarity).

Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity).

Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).

(Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity.
Biological Process
Central nervous system neuron development Source: UniProtKB
Cerebral cortex development Source: UniProtKB
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Establishment or maintenance of polarity of embryonic epithelium Source: GO_Central
Gene expression Source: Ensembl
Generation of neurons Source: GO_Central
Morphogenesis of an epithelial sheet Source: UniProtKB
Myelin assembly Source: Ensembl
Peripheral nervous system myelin maintenance Source: Ensembl
Protein localization to myelin sheath abaxonal region Source: Ensembl
Protein localization to plasma membrane Source: GO_Central
Regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Cellular Location
Golgi apparatus
Plasma membrane
Cell membrane
Apical cell membrane
Other locations
Endomembrane system
tight junction
adherens junction
axon
Perikaryon
Note: Localized to the tight junctions of epithelial cells (By similarity). Localized to the Golgi apparatus in T lymphocytes (PubMed:21479189). Localized to a subset of intracellular vesicles (By similarity). Localized to the Purkinje cell body and axon (By similarity). Localized to intercellular junctions in vascular endothelial cells (PubMed:27466317). Localized to Schmidt-Lanterman incisures, the adaxonal domain, and the inner part of paranodal loops in myelinating Schwann cells of the sciatic nerve (By similarity). Localized to apical membrane domains of the outer limiting membrane (OLM) junctions in the retina (By similarity). Colocalizes with CRB1 at the OLM, apical to the adherens junction (PubMed:15914641). Colocalizes with MPP1 in the retina at the OLM (PubMed:17584769). Colocalizes with MPP3 to the subapical region of adherens junctions in the retina OLM (PubMed:16519681).
Golgi apparatus
Other locations
Endoplasmic reticulum-Golgi intermediate compartment
Note: (Microbial infection) Following infection by human SARS coronavirus, partially localized at the site of viral replication; the endoplasmic reticulum-Golgi intermediate compartment, reducing its levels at cell-cell contacts which results in delayed formation of tight junctions and affects establishment of cell polarity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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