NDRG4

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]

Full Name

NDRG Family Member 4

Function

Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity).

May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.

Biological Process

Brain development Source: GO_Central
Cardiac muscle cell proliferation Source: BHF-UCL
Cell differentiation Source: UniProtKB
Cell migration involved in heart development Source: Ensembl
Embryonic heart tube development Source: BHF-UCL
Heart looping Source: BHF-UCL
Negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of smooth muscle cell migration Source: BHF-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of neuron projection development Source: BHF-UCL
Regulation of endocytic recycling Source: Ensembl
Signal transduction Source: GO_Central
Vesicle docking Source: Ensembl
Visual learning Source: Ensembl

Cellular Location

Cytosol

PTM

Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment.