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Rabbit Anti-NDRG4 Recombinant Antibody (D4A6) (CBMAB-N1590-WJ)

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Datasheet
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
D4A6
Application
WB, IP, IHC-P, IF
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
NDRG Family Member 4
Introduction
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]
Entrez Gene ID
Human65009
Mouse234593
Rat64457
Monkey712742
UniProt ID
HumanQ9ULP0
MouseQ8BTG7
RatQ9Z2L9
MonkeyF7GNI4
Alternative Names
NDRG Family Member 4; Vascular Smooth Muscle Cell-Associated Protein 8; N-Myc Downstream-Regulated Gene 4 Protein; Brain Development-Related Molecule 1; SMAP-8; BDM1;
Function
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity).

May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
Biological Process
Brain development Source: GO_Central
Cardiac muscle cell proliferation Source: BHF-UCL
Cell differentiation Source: UniProtKB
Cell migration involved in heart development Source: Ensembl
Embryonic heart tube development Source: BHF-UCL
Heart looping Source: BHF-UCL
Negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of smooth muscle cell migration Source: BHF-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of neuron projection development Source: BHF-UCL
Regulation of endocytic recycling Source: Ensembl
Signal transduction Source: GO_Central
Vesicle docking Source: Ensembl
Visual learning Source: Ensembl
Cellular Location
Cytosol
PTM
Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment.

Zuo, H., Liu, S., Li, X., & Hou, G. (2023). miR-23a-3p promotes the development of colon cancer by inhibiting the expression of NDRG4. Clinical and Translational Oncology, 25(4), 933-940.

Li, R., He, C., Shen, L., Wang, S., Shen, Y., Feng, F., ... & Zheng, J. (2021). NDRG4 sensitizes CRC cells to 5‑FU by upregulating DDIT3 expression Corrigendum in/10.3892/ol. 2022.13321. Oncology Letters, 22(5), 1-8.

Vaes, N., Schonkeren, S. L., Rademakers, G., Holland, A. M., Koch, A., Gijbels, M. J., ... & Melotte, V. (2021). Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2. EMBO reports, 22(6), e51913.

Kang, T., Qu, Q., Xie, Z., & Cao, B. (2020). NDRG4 alleviates Aβ1–40 induction of SH-SY5Y cell Injury via activation of BDNF-Inducing signalling pathways. Neurochemical Research, 45, 1492-1499.

Bagheri, H., Mosallaei, M., Bagherpour, B., Khosravi, S., Salehi, A. R., & Salehi, R. (2020). TFPI2 and NDRG4 gene promoter methylation analysis in peripheral blood mononuclear cells are novel epigenetic noninvasive biomarkers for colorectal cancer diagnosis. The Journal of Gene Medicine, 22(8), e3189.

Shi, H. H., Liu, H. E., & Luo, X. J. (2020). Hypermethylation-mediated silencing of NDRG4 promotes pancreatic ductal adenocarcinoma by regulating mitochondrial function. BMB reports, 53(12), 658.

Cheng, H., & Yan, W. (2020). MiR-433 regulates myocardial ischemia reperfusion injury by targeting NDRG4 via the PI3K/Akt pathway. Shock, 54(6), 802-809.

Wen, L., Liu, L., Li, J., Tong, L., Zhang, K., Zhang, Q., & Li, C. (2019). NDRG4 protects against cerebral ischemia injury by inhibiting p53-mediated apoptosis. Brain Research Bulletin, 146, 104-111.

Wen, L., Liu, L., Tong, L., Li, J., Zhang, K., Zhang, Q., & Li, C. (2019). NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis. Genes & Diseases, 6(4), 448-454.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-NDRG4 Recombinant Antibody (2G3) (CAT#: CBMAB-N1588-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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