NEK7

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
Full Name
NIMA Related Kinase 7
Function
Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132).

Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596).

Phosphorylates RPS6KB1 (By similarity).

Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757).

Essential protein for NLRP3 inflammasome assembly and activation that acts downstream stimuli such as K+ efflux. Dispensable for the induction of core inflammasome components, but necessary for subsequent formation of the NLRP3:PYCARD complex, and activation of CASP1. Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division. Exerts its effects on the NLRP3 inflammasome independently of its kinase activity (PubMed:26642356).
Biological Process
Cellular response to potassium ion Source: UniProtKB
Positive regulation of NLRP3 inflammasome complex assembly Source: UniProtKB
Positive regulation of telomerase activity Source: BHF-UCL
Positive regulation of telomere capping Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein phosphorylation Source: UniProtKB
Regulation of mitotic cell cycle Source: UniProtKB
Spindle assembly Source: UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoskeleton
spindle pole
centrosome
Note: Present at centrosome throughout the cell cycle (PubMed:17586473). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (PubMed:17586473). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity).
PTM
Phosphorylation at Ser-195 required for its activation.
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Anti-NEK7 antibodies

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Rabbit Anti-NEK7 Recombinant Antibody (H.691.4) (CBMAB-N1947-WJ)

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Target: NEK7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: H.691.4
Application*: WB
Datasheet SDS

Rabbit Anti-NEK7 Recombinant Antibody (CBWJN-1322) (CBMAB-N1946-WJ)

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Target: NEK7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1322
Application*: WB, F
Datasheet SDS

Rat Recombinant NEK7 protein, GST Tag (V2LY-0526-LY9529)

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Target: NEK7
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-302
Tag: GST Tag
Datasheet SDS

Rabbit Recombinant NEK7 protein, GST Tag (V2LY-0526-LY9138)

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Target: NEK7
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-302
Tag: GST Tag
Datasheet SDS

Mouse Recombinant NEK7 protein, GST Tag (V2LY-0526-LY8697)

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Target: NEK7
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-302
Tag: GST Tag
Datasheet SDS

Human Recombinant NEK7 protein, GST Tag (V2LY-0526-LY5742)

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Target: NEK7
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-302
Tag: GST Tag
Datasheet SDS

Human Recombinant NEK7, Active protein, GST Tag (V2LY-0526-LY5741)

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Target: NEK7
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS

Cynomolgus Recombinant NEK7 protein, GST Tag (V2LY-0526-LY1610)

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Target: NEK7
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-302
Tag: GST Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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