NEK7

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]

Full Name

NIMA Related Kinase 7

Function

Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132).

Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596).

Phosphorylates RPS6KB1 (By similarity).

Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757).

Essential protein for NLRP3 inflammasome assembly and activation that acts downstream stimuli such as K+ efflux. Dispensable for the induction of core inflammasome components, but necessary for subsequent formation of the NLRP3:PYCARD complex, and activation of CASP1. Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division. Exerts its effects on the NLRP3 inflammasome independently of its kinase activity (PubMed:26642356).

Biological Process

Cellular response to potassium ion Source: UniProtKB
Positive regulation of NLRP3 inflammasome complex assembly Source: UniProtKB
Positive regulation of telomerase activity Source: BHF-UCL
Positive regulation of telomere capping Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein phosphorylation Source: UniProtKB
Regulation of mitotic cell cycle Source: UniProtKB
Spindle assembly Source: UniProtKB

Cellular Location

Cytoplasm
Nucleus
Cytoskeleton
spindle pole
centrosome
Note: Present at centrosome throughout the cell cycle (PubMed:17586473). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (PubMed:17586473). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity).

PTM

Phosphorylation at Ser-195 required for its activation.