OPN5

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants.

Full Name

Opsin 5

Function

G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity).
Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319).
Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity).
Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity).
Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity).
Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity).
Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity).

Biological Process

Cellular response to light stimulusISS:UniProtKB
Cellular response to UV-AManual Assertion Based On ExperimentIDA:UniProtKB
Entrainment of circadian clock by photoperiodISS:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Hyaloid vascular plexus regressionISS:UniProtKB
PhototransductionISS:UniProtKB
Phototransduction, UVManual Assertion Based On ExperimentIMP:UniProtKB
Protein-chromophore linkageIEA:UniProtKB-KW
Visual perceptionIEA:UniProtKB-KW

Cellular Location

Cell membrane

Topology

Extracellular: 1-33
Helical: 34-54
Cytoplasmic: 55-74
Helical: 75-95
Extracellular: 96-108
Helical: 109-129
Cytoplasmic: 130-150
Helical: 151-171
Extracellular: 172-197
Helical: 198-218
Cytoplasmic: 219-252
Helical: 253-273
Extracellular: 274-288
Helical: 289-309
Cytoplasmic: 310-353

PTM

It is uncertain whether Cys-315 or Cys-316 is palmitoylated.