OXT

This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.

Oxytocin/Neurophysin I Prepropeptide

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156).

Drinking behaviorIEA:Ensembl
Eating behaviorIEA:Ensembl
Female pregnancyIEA:Ensembl
Grooming behaviorIEA:Ensembl
Heart developmentIEA:Ensembl
Hyperosmotic salinity responseIEA:Ensembl
Male mating behaviorIEA:Ensembl
Maternal aggressive behaviorIEA:Ensembl
Maternal behaviorIEA:Ensembl
MemoryIEA:Ensembl
Negative regulation of blood pressureIEA:Ensembl
Negative regulation of gastric acid secretionIEA:Ensembl
Negative regulation of urine volumeIEA:Ensembl
Positive regulation of blood pressureIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Positive regulation of female receptivityIEA:Ensembl
Positive regulation of hindgut contractionIEA:Ensembl
Positive regulation of norepinephrine secretionIEA:Ensembl
Positive regulation of ossificationIEA:Ensembl
Positive regulation of penile erectionIEA:Ensembl
Positive regulation of prostaglandin secretionIEA:Ensembl
Positive regulation of renal sodium excretionIEA:Ensembl
Positive regulation of synapse assemblyIEA:Ensembl
Positive regulation of synaptic transmissionIEA:Ensembl
Positive regulation of uterine smooth muscle contractionIEA:Ensembl
Regulation of heart rateIEA:Ensembl
Regulation of sensory perception of painIEA:Ensembl
Response to activityIEA:Ensembl
Response to amphetamineIEA:Ensembl
Response to cAMPIEA:Ensembl
Response to cocaineIEA:Ensembl
Response to electrical stimulusIEA:Ensembl
Response to estradiolIEA:Ensembl
Response to etherIEA:Ensembl
Response to foodIEA:Ensembl
Response to glucocorticoidIEA:Ensembl
Response to peptide hormoneIEA:Ensembl
Response to progesteroneIEA:Ensembl
Response to prostaglandin EIEA:Ensembl
Response to retinoic acidIEA:Ensembl
Response to sucroseIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
SleepIEA:Ensembl
Social behaviorIEA:Ensembl
Sperm ejaculationIEA:Ensembl

Secreted