PRSS1

PRSS1 is a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis.

Full Name

Serine Protease 1

Function

Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

Biological Process

DigestionIEA:UniProtKB-KW
Extracellular matrix disassemblyTAS:Reactome
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space

Involvement in disease

Pancreatitis, hereditary (PCTT):
A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.

PTM

Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.
Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.

Anti-PRSS1 antibodies

Mouse Anti-PRSS1 Recombinant Antibody (7C8) (CBMAB-T0628-YJ)

Datasheet

SDS

Target: PRSS1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Cattle

Clone: 7C8

Application*: WB, E

Mouse Anti-PRSS1 Recombinant Antibody (CBYJT-1584) (CBMAB-T0626-YJ)

Datasheet

SDS

Target: PRSS1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-1584

Application*: E

Mouse Anti-PRSS1 Recombinant Antibody (CBYJT-1583) (CBMAB-T0625-YJ)

Datasheet

SDS

Target: PRSS1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-1583

Application*: E

Rabbit Anti-PRSS1 Recombinant Antibody (CBYJT-1582) (CBMAB-T0623-YJ)

Datasheet

SDS

Target: PRSS1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1582

Application*: E, WB, IP

Mouse Anti-PRSS1 Recombinant Antibody (404) (CBMAB-T0622-YJ)

Datasheet

SDS

Target: PRSS1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 404

Application*: E

Mouse Anti-PRSS1 Recombinant Antibody (CBYJT-1580) (CBMAB-T0620-YJ)

Datasheet

SDS

Target: PRSS1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-1580

Application*: IA, E

Mouse Anti-PRSS1 Recombinant Antibody (CBYJT-1579) (CBMAB-T0619-YJ)

Datasheet

SDS

Target: PRSS1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-1579

Application*: WB, E

Mouse Anti-PRSS1 Recombinant Antibody (CBYC-P670) (CBMAB-P3056-YC)

Datasheet

SDS

Target: PRSS1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYC-P670

Application*: E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)