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Mouse Anti-PRSS1 Recombinant Antibody (CBYJT-1579) (CBMAB-T0619-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to PRSS1 (Serine Protease 1). The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all PRSS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1579
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
Trypsin purified from human pancreatic tissue and adsorbed onto aluminum hydroxide gel (2)
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine Protease 1
Introduction
PRSS1 is a trypsinogen, which is a member of the trypsin family of serine proteases. PRSS1 is secreted by the pancreas and cleaved to its active form in the small intestine. PRSS1 is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in PRSS1 are associated with hereditary pancreatitis.
Entrez Gene ID
5644
UniProt ID
P07477
Alternative Names
TRP1; TRY1; TRY4; TRYP1
Function
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
Biological Process
DigestionIEA:UniProtKB-KW
Extracellular matrix disassemblyTAS:Reactome
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space
Involvement in disease
Pancreatitis, hereditary (PCTT):
A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
PTM
Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.
Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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