RAB26

Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]). [supplied by OMIM, Nov 2010]

Full Name

RAB26, member RAS oncogene family

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.

Biological Process

Biological Process exocrine system developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulated exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of exocytosisISS:UniProtKB
Biological Process regulation of protein catabolic process at presynapse, modulating synaptic transmissionManual Assertion Based On ExperimentIDA:SynGO

Cellular Location

Golgi apparatus membrane
Cytoplasmic vesicle, secretory vesicle membrane
Not localized at the plasma membrane (By similarity).
Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location