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Mouse Anti-RAB26 Recombinant Antibody (163E12) (CBMAB-R0772-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
163E12
Antibody Isotype
IgG2a
Application
WB, ICC

Basic Information

Immunogen
Full length recombinant human Rab 26
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH

Target

Full Name
RAB26, member RAS oncogene family
Introduction
Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]). [supplied by OMIM, Nov 2010]
Entrez Gene ID
Human25837
Mouse328778
Rat171111
UniProt ID
HumanQ9ULW5
MouseQ504M8
RatP51156
Alternative Names
RAB26, Member RAS Oncogene Family; Ras-Related Oncogene Protein; Ras-Related Protein Rab-26; V46133;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.
Biological Process
Biological Process exocrine system developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulated exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of exocytosisISS:UniProtKB
Biological Process regulation of protein catabolic process at presynapse, modulating synaptic transmissionManual Assertion Based On ExperimentIDA:SynGO
Cellular Location
Golgi apparatus membrane
Cytoplasmic vesicle, secretory vesicle membrane
Not localized at the plasma membrane (By similarity).
Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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