RAB2B

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM

Full Name

RAB2B, member RAS oncogene family

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity).

Biological Process

Biological Process defense response to virusISS:UniProtKB
Biological Process Golgi organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune responseISS:UniProtKB
Biological Process positive regulation of exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of type I interferon productionISS:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus membrane
Cytoplasmic vesicle, secretory vesicle, acrosome
Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid.