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RFC2

This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]
Full Name
Replication Factor C Subunit 2
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).
Biological Process
Biological Process DNA duplex unwindingIEA:GOC
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA-templated DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of DNA-directed DNA polymerase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Involvement in disease
RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:11003705).
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Anti-RFC2 antibodies

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Mouse Anti-RFC2 Recombinant Antibody (5A1) (CBMAB-R2322-CN)

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Target: RFC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A1
Application*: F, P, WB
Datasheet SDS

Mouse Anti-RFC2 Recombinant Antibody (4E1) (CBMAB-R2321-CN)

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Target: RFC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E1
Application*: WB, F
Datasheet SDS

Mouse Anti-RFC2 Recombinant Antibody (4C5) (CBMAB-R2320-CN)

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Target: RFC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C5
Application*: WB
Datasheet SDS

Mouse Anti-RFC2 Recombinant Antibody (4C11) (CBMAB-R2319-CN)

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Target: RFC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C11
Application*: WB, P, F
Datasheet SDS

Mouse Anti-RFC2 Recombinant Antibody (3F6) (CBMAB-R2318-CN)

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Target: RFC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F6
Application*: WB, IH
Datasheet SDS

Mouse Anti-RFC2 Recombinant Antibody (3A7) (CBMAB-R2317-CN)

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Target: RFC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A7
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-RFC2 Recombinant Antibody (2B2) (CBMAB-R2316-CN)

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Target: RFC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B2
Application*: WB, F, IH
Datasheet SDS

Mouse Anti-RFC2 Recombinant Antibody (11C6) (CBMAB-R2315-CN)

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Target: RFC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11C6
Application*: WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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