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Mouse Anti-RFC2 Recombinant Antibody (4C11) (CBMAB-R2319-CN)

This product is a Mouse antibody that recognizes RFC2. The antibody 4C11 can be used for immunoassay techniques such as: WB, IHC-P, FC.
See all RFC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C11
Antibody Isotype
IgG1
Application
WB, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
Replication Factor C Subunit 2
Introduction
This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]
Entrez Gene ID
5982
UniProt ID
P35250
Alternative Names
Replication Factor C Subunit 2; Replication Factor C (Activator 1) 2, 40kDa; Activator 1 Subunit 2; RF-C 40 KDa Subunit; A1 40 KDa Subunit; RFC40;
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).
Biological Process
Biological Process DNA duplex unwindingIEA:GOC
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA-templated DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of DNA-directed DNA polymerase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Involvement in disease
RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:11003705).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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