RGMB

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]). [supplied by OMIM, Apr 2009]

Full Name

Repulsive Guidance Molecule Family Member B

Function

Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity).
Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity).
Promotes neuronal adhesion (By similarity).
May inhibit neurite outgrowth.

Biological Process

Biological Process BMP signaling pathwayISS:HGNC-UCL
Biological Process cell adhesionISS:HGNC-UCL
Biological Process positive regulation of transcription, DNA-templatedISS:HGNC-UCL
Biological Process signal transductionISS:HGNC-UCL

Cellular Location

Cell membrane
Membrane raft

PTM

GPI-anchored.
Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.

Anti-RGMB antibodies

Mouse Anti-RGMB Recombinant Antibody (398528) (CBMAB-R2420-CN)

Datasheet

SDS

Target: RGMB

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 398528

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)