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Mouse Anti-RGMB Recombinant Antibody (398528) (CBMAB-R2420-CN)

This product is a Mouse antibody that recognizes RGMB. The antibody 398528 can be used for immunoassay techniques such as: WB.
See all RGMB antibodies
Published Data
Fig.1 RGMb expression in mouse macrophages and RGMb protein structure.
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Fig.2 SKBR-3 cells were stained for RGMb.
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Fig.3 RGMb expression in lung AM and IM by Western blotting.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
398528
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human RGM-B isoform 1, Gly46-Ser411, Accession # Q6NW40
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, Trehalose
Concentration
LYOPH

Target

Full Name
Repulsive Guidance Molecule Family Member B
Introduction
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]). [supplied by OMIM, Apr 2009]
Entrez Gene ID
285704
UniProt ID
Q6NW40
Alternative Names
Repulsive Guidance Molecule Family Member B; DRG11-Responsive Axonal Guidance And Outgrowth Of Neurite; RGM Domain Family, Member B; DRAGON; Repulsive Guidance Molecule B; RGM Domain Family Member B;
Function
Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity).
Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity).
Promotes neuronal adhesion (By similarity).
May inhibit neurite outgrowth.
Biological Process
Biological Process BMP signaling pathwayISS:HGNC-UCL
Biological Process cell adhesionISS:HGNC-UCL
Biological Process positive regulation of transcription, DNA-templatedISS:HGNC-UCL
Biological Process signal transductionISS:HGNC-UCL
Cellular Location
Cell membrane
Membrane raft
PTM
GPI-anchored.
Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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