RNPC2

The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq]

Full Name

RNA binding motif protein 39

Function

RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046).
Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494).
Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).

Biological Process

Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA splicingIEA:UniProtKB-KW

Cellular Location

Nucleus speckle
Concentrated in nuclear speckles (PubMed:8227358).
Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358).

PTM

Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:31693891, PubMed:28437394, PubMed:28302793).
RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:31693891, PubMed:28437394, PubMed:28302793).
Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272).