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Mouse Anti-RNPC2 Recombinant Antibody (4G8) (CBMAB-A7684-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
4G8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
RNPC2 (NP_909122, 423 a.a. ~ 472 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RNA binding motif protein 39
Introduction
The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq]
Entrez Gene ID
Human9584
Mouse170791
UniProt ID
HumanQ14498
MouseQ8VH51
Alternative Names
CAPER; CAPERalpha; CC1.3; DKFZp781C0423; FLJ44170; HCC1; RNPC2; fSAP59
Function
RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046).
Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494).
Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).
Biological Process
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA splicingIEA:UniProtKB-KW
Cellular Location
Nucleus speckle
Concentrated in nuclear speckles (PubMed:8227358).
Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358).
PTM
Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:31693891, PubMed:28437394, PubMed:28302793).
RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:31693891, PubMed:28437394, PubMed:28302793).
Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272).
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For research use only. Not intended for any clinical use.

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