S. cerevisiae COX4

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.

cytochrome c oxidase subunit IV

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Biological Process cellular respirationIDA:ComplexPortal
Biological Process mitochondrial cytochrome c oxidase assemblyManual Assertion Based On ExperimentIMP:CACAO
Biological Process mitochondrial electron transport, cytochrome c to oxygenManual Assertion Based On ExperimentIDA:SGD
Biological Process proton transmembrane transportIEA:GOC

Mitochondrion inner membrane