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SERPINC1

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
Full Name
Serpin Family C Member 1
Function
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15853774, PubMed:15140129).
AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129).
Its inhibitory activity is greatly enhanced in the presence of heparin.
Biological Process
Biological Process blood coagulationIEA:UniProtKB-KW
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of blood coagulation, intrinsic pathwayIEA:InterPro
Cellular Location
Secreted, extracellular space
Involvement in disease
Antithrombin III deficiency (AT3D):
An important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. Antithrombin-III deficiency is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
PTM
Phosphorylated by FAM20C in the extracellular medium.
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Anti-SERPINC1 antibodies

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Mouse Anti-SERPINC1 Recombinant Antibody (CF392) (CBMAB-FT455LY)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CF392
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (2B12) (CBMAB-A8002-LY)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B12
Application*: WB, E
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-6176) (CBMAB-S6446-CQ)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-6176
Application*: E, P, WB
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-3123) (CBMAB-S5867-CQ)

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Target: SERPINC1
Host: Mouse
Specificity: Human
Clone: CBXS-3123
Application*: E, WB
Datasheet SDS

Rat Anti-SERPINC1 Recombinant Antibody (CBXS-1699) (CBMAB-S4537-CQ)

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Target: SERPINC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-1699
Application*: WB
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-0249) (CBMAB-S3226-CQ)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0249
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-5262) (CBMAB-S2477-CQ)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-5262
Application*: E, WB
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-4387) (CBMAB-S1630-CQ)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXS-4387
Application*: E, WB, IH, IF
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-3887) (CBMAB-S1156-CQ)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3887
Application*: E
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-5929) (CBMAB-S0778-CQ)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5929
Application*: F
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-5648) (CBMAB-S0524-CQ)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXS-5648
Application*: WB
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-4520) (CBMAB-S0230-CQ)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4520
Application*: E, IH, P
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (CBYC-A1043) (CBMAB-A4763-YC)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A1043
Application*: E, WB
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (BDI205) (CBMAB-A4762-YC)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BDI205
Application*: WB, IP, E, P, DB, B, IC, IF
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (8D5) (CBMAB-A4761-YC)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 8D5
Application*: WB, F
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (3G9) (CBMAB-A4757-YC)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3G9
Application*: E, WB
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (2E10) (CBMAB-A4756-YC)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E10
Application*: E, IH
Datasheet SDS

Mouse Anti-SERPINC1 Recombinant Antibody (1B7) (CBMAB-A4755-YC)

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Target: SERPINC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B7
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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