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SERPINC1

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

Full Name

Serpin Family C Member 1

Function

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15853774, PubMed:15140129).
AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129).
Its inhibitory activity is greatly enhanced in the presence of heparin.

Biological Process

Biological Process blood coagulationIEA:UniProtKB-KW
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of blood coagulation, intrinsic pathwayIEA:InterPro

Cellular Location

Secreted, extracellular space

Involvement in disease

Antithrombin III deficiency (AT3D):
An important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. Antithrombin-III deficiency is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.

PTM

Phosphorylated by FAM20C in the extracellular medium.

Anti-SERPINC1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-SERPINC1 Recombinant Antibody (CF392) (CBMAB-FT455LY)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CF392

Application*: ELISA, WB

Mouse Anti-SERPINC1 Recombinant Antibody (2B12) (CBMAB-A8002-LY)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2B12

Application*: WB, E

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-6176) (CBMAB-S6446-CQ)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-6176

Application*: E, P, WB

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-3123) (CBMAB-S5867-CQ)

SDS

Target: SERPINC1

Host: Mouse

Specificity: Human

Clone: CBXS-3123

Application*: E, WB

Rat Anti-SERPINC1 Recombinant Antibody (CBXS-1699) (CBMAB-S4537-CQ)

SDS

Target: SERPINC1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXS-1699

Application*: WB

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-0249) (CBMAB-S3226-CQ)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-0249

Application*: E, WB, IH

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-5262) (CBMAB-S2477-CQ)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-5262

Application*: E, WB

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-4387) (CBMAB-S1630-CQ)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBXS-4387

Application*: E, WB, IH, IF

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-3887) (CBMAB-S1156-CQ)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-3887

Application*: E

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-5929) (CBMAB-S0778-CQ)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-5929

Application*: F

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-5648) (CBMAB-S0524-CQ)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBXS-5648

Application*: WB

Mouse Anti-SERPINC1 Recombinant Antibody (CBXS-4520) (CBMAB-S0230-CQ)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-4520

Application*: E, IH, P

Mouse Anti-SERPINC1 Recombinant Antibody (CBYC-A1043) (CBMAB-A4763-YC)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-A1043

Application*: E, WB

Mouse Anti-SERPINC1 Recombinant Antibody (BDI205) (CBMAB-A4762-YC)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: BDI205

Application*: WB, IP, E, P, DB, B, IC, IF

Mouse Anti-SERPINC1 Recombinant Antibody (8D5) (CBMAB-A4761-YC)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 8D5

Application*: WB, F

Mouse Anti-SERPINC1 Recombinant Antibody (3G9) (CBMAB-A4757-YC)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3G9

Application*: E, WB

Mouse Anti-SERPINC1 Recombinant Antibody (2E10) (CBMAB-A4756-YC)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2E10

Application*: E, IH

Mouse Anti-SERPINC1 Recombinant Antibody (1B7) (CBMAB-A4755-YC)

SDS

Target: SERPINC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1B7

Application*: E, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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