Mouse Anti-SERPINC1 Recombinant Antibody (BDI205) (CBMAB-A4762-YC)

Name: Mouse Anti-SERPINC1 Recombinant Antibody (BDI205)
SKU: CBMAB-A4762-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

BDI205

Application

WB, IP, ELISA, IHC-P, Dot, BL, ICC, IF

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Serpin Family C Member 1

Introduction

SERPINC1 is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two

Entrez Gene ID

462

UniProt ID

P01008

Alternative Names

Serpin Family C Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade C (Antithrombin), Member 1; Serpin Peptidase Inhibitor, Clade C (Antithrombin), Member 1; ATIII; AT3; Coding Sequence Signal Peptide Antithrombin Part 1; Serpin Peptidase Inhibitor

Function

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15853774, PubMed:15140129).
AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129).
Its inhibitory activity is greatly enhanced in the presence of heparin.

Biological Process

Biological Process blood coagulationIEA:UniProtKB-KW
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of blood coagulation, intrinsic pathwayIEA:InterPro

Cellular Location

Secreted, extracellular space

Involvement in disease

Antithrombin III deficiency (AT3D):
An important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. Antithrombin-III deficiency is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.

PTM

Phosphorylated by FAM20C in the extracellular medium.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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