SFRP4

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.

Secreted Frizzled Related Protein 4

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity).
SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity).
Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).

Biological Process bone morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of non-canonical Wnt signaling pathwayISS:UniProtKB
Biological Process negative regulation of sodium-dependent phosphate transportManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of Wnt signaling pathway1 PublicationNAS:ParkinsonsUK-UCL
Biological Process phosphate ion homeostasisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIGI:MGI
Biological Process positive regulation of epidermal cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of keratinocyte apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of BMP signaling pathwayISS:UniProtKB
Biological Process response to hormone1 PublicationNAS:BHF-UCL

Secreted
Cytoplasmic in ovarian tumor cells.

Pyle disease (PYL):
A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures.