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Mouse Anti-SFRP4 (AA 265-346) Recombinant Antibody (CBXS-0307) (CBMAB-S3282-CQ)

This product is a mouse antibody that recognizes SFRP4. The antibody CBXS-0307 can be used for immunoassay techniques such as: ELISA, WB.
See all SFRP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0307
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 265-346

Target

Full Name
Secreted Frizzled Related Protein 4
Introduction
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
Entrez Gene ID
6424
UniProt ID
Q6FHJ7
Alternative Names
Secreted Frizzled Related Protein 4; Secreted Frizzled-Related Protein 4; Frizzled Protein, Human Endometrium; SFRP-4; FRPHE; Secreted Frizzled-Related Protein 4; Secreted Frizzled-Related Protein 4; FRZB-2; FRP-4; PYL;
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity).
SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity).
Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
Biological Process
Biological Process bone morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of non-canonical Wnt signaling pathwayISS:UniProtKB
Biological Process negative regulation of sodium-dependent phosphate transportManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of Wnt signaling pathway1 PublicationNAS:ParkinsonsUK-UCL
Biological Process phosphate ion homeostasisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIGI:MGI
Biological Process positive regulation of epidermal cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of keratinocyte apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of BMP signaling pathwayISS:UniProtKB
Biological Process response to hormone1 PublicationNAS:BHF-UCL
Cellular Location
Secreted
Cytoplasmic in ovarian tumor cells.
Involvement in disease
Pyle disease (PYL):
A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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