SH2D1B

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM

Full Name

SH2 domain containing 1B

Function

Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425).
In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958).
Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity).
In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958).
Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process leukocyte activation involved in immune responseISS:UniProtKB
Biological Process positive regulation of innate immune responseISS:UniProtKB
Biological Process positive regulation of natural killer cell mediated immunityISS:UniProtKB
Biological Process positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of immune responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

cytosol