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Mouse Anti-SH2D1B Recombinant Antibody (2B4) (CBMAB-A8075-LY)

The product is antibody recognizes SH2D1B. The antibody 2B4 immunoassay techniques such as: IP, ELISA.
See all SH2D1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B4
Antibody Isotype
IgG2a, κ
Application
IP, ELISA

Basic Information

Immunogen
SH2D1B (NP_444512.2, 54 a.a. ~ 132 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SH2 domain containing 1B
Introduction
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM
Entrez Gene ID
117157
UniProt ID
O14796
Alternative Names
EAT2
Function
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425).
In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958).
Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity).
In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958).
Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process leukocyte activation involved in immune responseISS:UniProtKB
Biological Process positive regulation of innate immune responseISS:UniProtKB
Biological Process positive regulation of natural killer cell mediated immunityISS:UniProtKB
Biological Process positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of immune responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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