SLC25A25

The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene.

Full Name

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

Function

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

Biological Process

Biological Process adipose tissue developmentIEA:Ensembl
Biological Process ATP metabolic processIEA:Ensembl
Biological Process calcium ion transmembrane transportIEA:Ensembl
Biological Process camera-type eye developmentIEA:Ensembl
Biological Process cellular respirationIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process response to activityIEA:Ensembl
Biological Process response to dietary excessIEA:Ensembl
Biological Process response to foodIEA:Ensembl

Cellular Location

Mitochondrion inner membrane

Topology

Mitochondrial intermembrane: 1-189
Helical: 190-207
Mitochondrial matrix: 208-244
Helical: 245-264
Mitochondrial intermembrane: 265-287
Helical: 288-301
Mitochondrial matrix: 302-337
Helical: 338-357
Mitochondrial intermembrane: 358-380
Helical: 381-398
Mitochondrial matrix: 399-437
Helical: 438-457
Mitochondrial intermembrane: 458-469