SLURP1

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq]

Full Name

secreted LY6/PLAUR domain containing 1

Function

Has an antitumor activity (PubMed:8742060).
Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884).
In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431).
In T cells may be involved in regulation of intracellular Ca2+ signaling (PubMed:17286989).
Seems to have an immunomodulatory function in the cornea (By similarity).
The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).

Biological Process

Biological Process cell activation1 PublicationNAS:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process locomotory behaviorIEA:Ensembl
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of keratinocyte proliferationIEA:Ensembl
Biological Process neuromuscular process controlling postureIEA:Ensembl
Biological Process urokinase plasminogen activator signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted

Involvement in disease

Mal de Meleda (MDM):
A rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.