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Mouse Anti-SLURP1 (AA 22-103) Recombinant Antibody (CBXS-0511) (CBMAB-S3458-CQ)

This product is a mouse antibody that recognizes SLURP1. The antibody CBXS-0511 can be used for immunoassay techniques such as: ELISA, IHC.
See all SLURP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0511
Antibody Isotype
IgG2a
Application
ELISA, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 22-103

Target

Full Name
secreted LY6/PLAUR domain containing 1
Introduction
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.
Entrez Gene ID
57152
UniProt ID
P55000
Alternative Names
Secreted LY6/PLAUR Domain Containing 1; Lymphocyte Antigen 6-Like Secreted; Anti-Neoplastic Urinary Protein; ARS(Component B)-81/S; ARS Component B; SLURP-1; ANUP;
Function
Has an antitumor activity (PubMed:8742060).
Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884).
In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431).
In T cells may be involved in regulation of intracellular Ca2+ signaling (PubMed:17286989).
Seems to have an immunomodulatory function in the cornea (By similarity).
The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).
Biological Process
Biological Process cell activation1 PublicationNAS:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process locomotory behaviorIEA:Ensembl
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of keratinocyte proliferationIEA:Ensembl
Biological Process neuromuscular process controlling postureIEA:Ensembl
Biological Process urokinase plasminogen activator signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
Involvement in disease
Mal de Meleda (MDM):
A rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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