SSTR4

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.

Full Name

Somatostatin Receptor 4

Function

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Biological Process

Biological Process cell migrationIEA:Ensembl
Biological Process cellular response to glucocorticoid stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process forebrain developmentIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of arachidonic acid secretionIEA:Ensembl
Biological Process positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-46
Helical: 47-73
Cytoplasmic: 74-83
Helical: 84-104
Extracellular: 105-120
Helical: 121-142
Cytoplasmic: 143-161
Helical: 162-185
Extracellular: 186-208
Helical: 209-232
Cytoplasmic: 233-260
Helical: 261-280
Extracellular: 281-291
Helical: 292-314
Cytoplasmic: 315-388