Mouse Anti-SSTR4 Recombinant Antibody (CBXS-4575) (CBMAB-S1815-CQ)

Name: Mouse Anti-SSTR4 Recombinant Antibody (CBXS-4575)
SKU: CBMAB-S1815-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-4575

Application

Immunogen

Synthetic peptide corresponding to residues near C-terminus of human SSTR4 (NP_001043)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Somatostatin Receptor 4

Introduction

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.

Entrez Gene ID

6754

UniProt ID

P31391

Alternative Names

Somatostatin Receptor 4; SS-4-R; SS4-R; SS4R; Somatostatin Receptor Type 4; G-Protein Coupled Receptor;

Function

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Biological Process

Biological Process cell migrationIEA:Ensembl
Biological Process cellular response to glucocorticoid stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process forebrain developmentIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of arachidonic acid secretionIEA:Ensembl
Biological Process positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-46
Helical: 47-73
Cytoplasmic: 74-83
Helical: 84-104
Extracellular: 105-120
Helical: 121-142
Cytoplasmic: 143-161
Helical: 162-185
Extracellular: 186-208
Helical: 209-232
Cytoplasmic: 233-260
Helical: 261-280
Extracellular: 281-291
Helical: 292-314
Cytoplasmic: 315-388

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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