STXBP4

syntaxin binding protein 4

Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).

Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process insulin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell cycle G1/S phase transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein targetingIEA:Ensembl
Biological Process regulation of glucose transmembrane transportIEA:Ensembl
Biological Process regulation of insulin secretion involved in cellular response to glucose stimulusManual Assertion Based On ExperimentIDA:UniProtKB

Cytoplasm

Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A (By similarity).