Rabbit Anti-STXBP4 Recombinant Antibody (CBXS-6166) (CBMAB-S6381-CQ)

Name: Rabbit Anti-STXBP4 Recombinant Antibody (CBXS-6166)
SKU: CBMAB-S6381-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

CBXS-6166

Application

Immunogen

Synthetic peptide corresponding to the sequence of human Synip

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.01 M HEPES, 0.15 M NaCl, 0.1 mg/mL BSA, 50% glycerol, pH 7.5

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

syntaxin binding protein 4

Entrez Gene ID

Human	252983
Mouse	20913
Rat	303443

UniProt ID

Human	Q6ZWJ1
Mouse	Q9WV89
Rat	D3Z9G8

Alternative Names

Synip

Function

Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).

Biological Process

Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process insulin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell cycle G1/S phase transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein targetingIEA:Ensembl
Biological Process regulation of glucose transmembrane transportIEA:Ensembl
Biological Process regulation of insulin secretion involved in cellular response to glucose stimulusManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm

PTM

Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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