TAOK1

TAOK1 (TAO Kinase 1) is a protein coding gene. Diseases associated with TAOK1 include Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb. Among its related pathways are MAPK signaling pathway and Signaling by Rho GTPases. Gene Ontology annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TAOK3.

Full Name

TAO kinase 1

Function

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190).
Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity).

Biological Process

Biological Process cellular response to DNA damage stimulusIDA:UniProtKB1 Publication
Biological Process central nervous system neuron developmentIMP:UniProtKB1 Publication
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process execution phase of apoptosisIDA:UniProtKB1 Publication
Biological Process intracellular signal transductionIBA:GO_Central1 Publication
Biological Process MAPK cascadeIBA:GO_Central1 Publication
Biological Process microtubule cytoskeleton organizationIMP:ARUK-UCL1 Publication
Biological Process mitotic G2 DNA damage checkpoint signalingIMP:UniProtKB1 Publication
Biological Process negative regulation of microtubule depolymerizationIMP:ARUK-UCL1 Publication
Biological Process neuron cellular homeostasisIMP:ARUK-UCL1 Publication
Biological Process neuron projection morphogenesisIBA:GO_Central1 Publication
Biological Process phosphorylationIDA:ARUK-UCL1 Publication
Biological Process positive regulation of JNK cascadeIDA:UniProtKB1 Publication
Biological Process positive regulation of protein acetylationIMP:ARUK-UCL1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeIMP:UniProtKB1 Publication
Biological Process protein autophosphorylationISS:ARUK-UCLBy Similarity
Biological Process protein phosphorylationIBA:GO_Central1 Publication
Biological Process regulation of actin cytoskeleton organizationISS:ARUK-UCLBy Similarity
Biological Process regulation of cytoskeleton organizationISS:UniProtKB
Biological Process regulation of MAPK cascadeIBA:GO_Central1 Publication
Biological Process regulation of microtubule cytoskeleton organizationISS:ARUK-UCLBy Similarity

Cellular Location

Cytoplasm

Involvement in disease

Developmental delay with or without intellectual impairment or behavioral abnormalities (DDIB):
An autosomal dominant disorder characterized by a highly variable phenotype of developmental delay, intellectual disability, learning or behavioral problems, muscular hypotonia, and neonatal feeding difficulties.

PTM

Proteolytically processed by caspase-3 (CASP3).
Autophosphorylated (By similarity).
Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2