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Mouse Anti-TAOK1 Recombinant Antibody (CBYJT-1943) (CBMAB-T1028-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAOK1 (TAO Kinase 1). The antibody can be used for immunoassay techniques, such as WB.
See all TAOK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1943
Antibody Isotype
IgG3
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TAO kinase 1
Introduction
TAOK1 (TAO Kinase 1) is a Protein Coding gene. Diseases related to TAOK1 include Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb. Among its related pathways are MAPK signaling pathway and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to TAOK1 include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of TAOK1 is TAOK3.
Entrez Gene ID
57551
UniProt ID
Q7L7X3
Alternative Names
TAO Kinase 1; Thousand And One Amino Acid Protein Kinase 1; Prostate-Derived Sterile 20-Like Kinase 2; Prostate-Derived STE20-Like Kinase 2; Kinase From Chicken Homolog B; MARK Kinase; EC 2.7.11.1; MAP3K16; HKFC-B; HTAOK1; MARKK; PSK-2
Function
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190).
Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity).
Biological Process
Biological Process cellular response to DNA damage stimulusIDA:UniProtKB1 Publication
Biological Process central nervous system neuron developmentIMP:UniProtKB1 Publication
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process execution phase of apoptosisIDA:UniProtKB1 Publication
Biological Process intracellular signal transductionIBA:GO_Central1 Publication
Biological Process MAPK cascadeIBA:GO_Central1 Publication
Biological Process microtubule cytoskeleton organizationIMP:ARUK-UCL1 Publication
Biological Process mitotic G2 DNA damage checkpoint signalingIMP:UniProtKB1 Publication
Biological Process negative regulation of microtubule depolymerizationIMP:ARUK-UCL1 Publication
Biological Process neuron cellular homeostasisIMP:ARUK-UCL1 Publication
Biological Process neuron projection morphogenesisIBA:GO_Central1 Publication
Biological Process phosphorylationIDA:ARUK-UCL1 Publication
Biological Process positive regulation of JNK cascadeIDA:UniProtKB1 Publication
Biological Process positive regulation of protein acetylationIMP:ARUK-UCL1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeIMP:UniProtKB1 Publication
Biological Process protein autophosphorylationISS:ARUK-UCLBy Similarity
Biological Process protein phosphorylationIBA:GO_Central1 Publication
Biological Process regulation of actin cytoskeleton organizationISS:ARUK-UCLBy Similarity
Biological Process regulation of cytoskeleton organizationISS:UniProtKB
Biological Process regulation of MAPK cascadeIBA:GO_Central1 Publication
Biological Process regulation of microtubule cytoskeleton organizationISS:ARUK-UCLBy Similarity
Cellular Location
Cytoplasm
Involvement in disease
Developmental delay with or without intellectual impairment or behavioral abnormalities (DDIB):
An autosomal dominant disorder characterized by a highly variable phenotype of developmental delay, intellectual disability, learning or behavioral problems, muscular hypotonia, and neonatal feeding difficulties.
PTM
Proteolytically processed by caspase-3 (CASP3).
Autophosphorylated (By similarity).
Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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