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TDP1

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]

Full Name

TDP1 Gene(Protein Coding) Tyrosyl-DNA Phosphodiesterase 1

Function

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.

Biological Process

Biological Process DNA repairIDA:UniProtKB1 Publication
Biological Process double-strand break repairIDA:UniProtKB1 Publication
Biological Process single strand break repairIDA:UniProtKB1 Publication

Cellular Location

Nucleus
Cytoplasm

Involvement in disease

Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 (SCAN1):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.

PTM

Phosphorylated on serine and/or threonine residues, but not on tyrosine residues.

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Anti-TDP1 antibodies

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Rabbit Anti-TDP1 Recombinant Antibody (D8D1B) (CBMAB-CP2727-LY)

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Target: TDP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D8D1B

Application*: WB, IF (IC)

Mouse Anti-TDP1 Recombinant Antibody (2A10-G2) (CBMAB-A8989-LY)

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Target: TDP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2A10-G2

Application*: WB, E

TDP1 Matched Antibody Pair (1194) (APMAB-1194LY)

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Target: TDP1

Specificity: Human

TDP1 Matched Antibody Pair (1193) (APMAB-1193LY)

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Target: TDP1

Specificity: Human

Rabbit Anti-TDP1 Recombinant Antibody (CBYJT-2454) (CBMAB-T1601-YJ)

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Target: TDP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYJT-2454

Application*: WB, IF

Rabbit Anti-TDP1 Recombinant Antibody (CBYJT-2453) (CBMAB-T1600-YJ)

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Target: TDP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYJT-2453

Application*: IF, WB

Mouse Anti-TDP1 Recombinant Antibody (CBYJT-2452) (CBMAB-T1599-YJ)

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Target: TDP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-2452

Application*: E, P, WB

Mouse Anti-TDP1 Recombinant Antibody (AT1F2) (CBMAB-T1597-YJ)

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Target: TDP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: AT1F2

Application*: E, IH, WB

Mouse Anti-TDP1 Recombinant Antibody (CBYJT-2450) (CBMAB-T1596-YJ)

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Target: TDP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2450

Application*: WB

Mouse Anti-TDP1 Recombinant Antibody (CBYJT-2449) (CBMAB-T1595-YJ)

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Target: TDP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-2449

Application*: E, WB

Mouse Anti-TDP1 Recombinant Antibody (CBYJT-2447) (CBMAB-T1593-YJ)

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Target: TDP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-2447

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion

IEImmunoelectrophoresis
IFImmunofluorescence
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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