Sign in or Register   Sign in or Register
  |  

Rabbit Anti-TDP1 Recombinant Antibody (CBYJT-2453) (CBMAB-T1600-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TDP1 (Tyrosyl-DNA Phosphodiesterase 1). The antibody can be used for immunoassay techniques, such as IF, WB.
See all TDP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYJT-2453
Antibody Isotype
IgG
Application
IF, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Pro587 of human TDP1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
10 mM HEPES, 150 mM NaCl, pH 7.5, 100 μg/mL BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Residues surrounding Pro587

Target

Full Name
TDP1 Gene(Protein Coding) Tyrosyl-DNA Phosphodiesterase 1
Introduction
TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. TDP1 may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
Entrez Gene ID
Human55775
Mouse104884
Rat314380
UniProt ID
HumanQ9NUW8
MouseQ8BJ37
RatQ4G056
Alternative Names
Tyrosyl-DNA Phosphodiesterase 1; Tyr-DNA Phosphodiesterase 1; EC 3.1.4.-; EC 3.1.4
Function
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Biological Process
Biological Process DNA repairIDA:UniProtKB1 Publication
Biological Process double-strand break repairIDA:UniProtKB1 Publication
Biological Process single strand break repairIDA:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm
Involvement in disease
Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 (SCAN1):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.
PTM
Phosphorylated on serine and/or threonine residues, but not on tyrosine residues.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-TDP1 Recombinant Antibody (CBYJT-2453)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare