Human TDP1 ELISA Kit (V2LY-0626-LY5405)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.0098 ng/mL
Detection Range
0.02-7 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
68.4 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
TDP1 Gene(Protein Coding) Tyrosyl-DNA Phosphodiesterase 1
Function
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Biological Process
Biological Process DNA repairIDA:UniProtKB1 Publication
Biological Process double-strand break repairIDA:UniProtKB1 Publication
Biological Process single strand break repairIDA:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm
Involvement in disease
Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 (SCAN1):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.
PTM
Phosphorylated on serine and/or threonine residues, but not on tyrosine residues.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

TDP1 Matched Antibody Pair (1193) (CAT#: APMAB-1193LY)

TDP1 Matched Antibody Pair (1194) (CAT#: APMAB-1194LY)

Antibody Pairs

TDP1 Matched Antibody Pair (1193) (CAT#: APMAB-1193LY)

TDP1 Matched Antibody Pair (1194) (CAT#: APMAB-1194LY)

Related Products

Mouse Anti-TDP1 Recombinant Antibody (CBYJT-2447) (CAT#: CBMAB-T1593-YJ)

TDP1 Matched Antibody Pair (1193) (CAT#: APMAB-1193LY)

Mouse Anti-TDP1 Recombinant Antibody (2A10-G2) (CAT#: CBMAB-A8989-LY)

Rabbit Anti-TDP1 Recombinant Antibody (CBYJT-2454) (CAT#: CBMAB-T1601-YJ)

TDP1 Matched Antibody Pair (1194) (CAT#: APMAB-1194LY)

Mouse Anti-TDP1 Recombinant Antibody (CBYJT-2449) (CAT#: CBMAB-T1595-YJ)

Rabbit Anti-TDP1 Recombinant Antibody (CBYJT-2453) (CAT#: CBMAB-T1600-YJ)

Mouse Anti-TDP1 Recombinant Antibody (CBYJT-2452) (CAT#: CBMAB-T1599-YJ)

Rabbit Anti-TDP1 Recombinant Antibody (D8D1B) (CAT#: CBMAB-CP2727-LY)

Mouse Anti-TDP1 Recombinant Antibody (AT1F2) (CAT#: CBMAB-T1597-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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