TFIP11

This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Full Name

TFIP11 Tuftelin Interacting Protein 11

Function

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.

Biological Process

Biological Process biomineral tissue developmentSource:UniProtKB-KW
Biological Process mRNA splicing, via spliceosomeSource:UniProtKB1 Publication
Biological Process negative regulation of DNA ligase activitySource:BHF-UCL1 Publication
Biological Process negative regulation of double-strand break repair via nonhomologous end joiningSource:BHF-UCLBy Similarity
Biological Process negative regulation of protein bindingSource:BHF-UCL1 Publication
Biological Process negative regulation of protein-containing complex assemblySource:BHF-UCL1 Publication
Biological Process protection from non-homologous end joining at telomereSource:BHF-UCL1 Publication
Biological Process RNA processingSource:UniProtKB1 Publication
Biological Process spliceosomal complex disassemblySource:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.