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Mouse Anti-TFIP11 Recombinant Antibody (CBYJT-2700) (CBMAB-T1888-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TFIP11 (Tuftelin Interacting Protein 11). The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC.
See all TFIP11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2700
Antibody Isotype
IgG1
Application
ELISA, WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TFIP11 Tuftelin Interacting Protein 11
Introduction
TFIP11 is a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. TFIP11 contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. TFIP11 contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis.
Entrez Gene ID
24144
UniProt ID
Q9UBB9
Alternative Names
Tuftelin Interacting Protein 11; Septin And Tuftelin-Interacting Protein 1; STIP-1; StIP; Sip1/Tuftelin Interacting Protein; Tuftelin-Interacting Protein 11
Function
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
Biological Process
Biological Process biomineral tissue developmentSource:UniProtKB-KW
Biological Process mRNA splicing, via spliceosomeSource:UniProtKB1 Publication
Biological Process negative regulation of DNA ligase activitySource:BHF-UCL1 Publication
Biological Process negative regulation of double-strand break repair via nonhomologous end joiningSource:BHF-UCLBy Similarity
Biological Process negative regulation of protein bindingSource:BHF-UCL1 Publication
Biological Process negative regulation of protein-containing complex assemblySource:BHF-UCL1 Publication
Biological Process protection from non-homologous end joining at telomereSource:BHF-UCL1 Publication
Biological Process RNA processingSource:UniProtKB1 Publication
Biological Process spliceosomal complex disassemblySource:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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