Mouse Anti-TFIP11 Recombinant Antibody (CBYJT-2700) (CBMAB-T1888-YJ)

Name: Mouse Anti-TFIP11 Recombinant Antibody (CBYJT-2700)
SKU: CBMAB-T1888-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2700

Application

ELISA, WB, IHC

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TFIP11 Tuftelin Interacting Protein 11

Introduction

TFIP11 is a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. TFIP11 contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. TFIP11 contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis.

Entrez Gene ID

24144

UniProt ID

Q9UBB9

Alternative Names

Tuftelin Interacting Protein 11; Septin And Tuftelin-Interacting Protein 1; STIP-1; StIP; Sip1/Tuftelin Interacting Protein; Tuftelin-Interacting Protein 11

Function

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.

Biological Process

Biological Process biomineral tissue developmentSource:UniProtKB-KW
Biological Process mRNA splicing, via spliceosomeSource:UniProtKB1 Publication
Biological Process negative regulation of DNA ligase activitySource:BHF-UCL1 Publication
Biological Process negative regulation of double-strand break repair via nonhomologous end joiningSource:BHF-UCLBy Similarity
Biological Process negative regulation of protein bindingSource:BHF-UCL1 Publication
Biological Process negative regulation of protein-containing complex assemblySource:BHF-UCL1 Publication
Biological Process protection from non-homologous end joining at telomereSource:BHF-UCL1 Publication
Biological Process RNA processingSource:UniProtKB1 Publication
Biological Process spliceosomal complex disassemblySource:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-TFIP11 Recombinant Antibody (CF433) (CAT#: CBMAB-FT087LY)

Isotype control

For research use only. Not intended for any clinical use.

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