TNN

TNN (Tenascin N) is a Protein Coding gene. Diseases related to TNN include Adhesive Otitis Media and Chronic Purulent Otitis Media. Among its related pathways are ECM proteoglycans and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to TNN include identical protein binding and integrin binding. An important paralog of TNN is TNC.

Full Name

Tenascin N

Function

Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022).
Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity).
During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity).
In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).

Biological Process

Biological Process axonogenesis Source:Ensembl
Biological Process cell-matrix adhesion Source:GO_Central1 Publication
Biological Process dendrite self-avoidance Source:UniProtKB1 Publication
Biological Process negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation Source:UniProtKB
Biological Process negative regulation of neuron migration Source:UniProtKB1 Publication
Biological Process negative regulation of osteoblast differentiation Source:UniProtKB
Biological Process negative regulation of osteoblast proliferation Source:UniProtKB
Biological Process neuron projection extension Source:GO_Central1 Publication
Biological Process osteoblast development Source:UniProtKB
Biological Process positive regulation of neuron projection development Source:Ensembl
Biological Process positive regulation of sprouting angiogenesis Source:ComplexPortal1 Publication
Biological Process regulation of bone development Source:Ensembl
Biological Process regulation of cell adhesion Source:ComplexPortal1 Publication
Biological Process regulation of cell migration Source:ComplexPortal1 Publication
Biological Process regulation of smooth muscle tissue development Source:Ensembl

Cellular Location

Secreted, extracellular space, extracellular matrix