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Mouse Anti-TNN Recombinant Antibody (CBYJT-4040) (CBMAB-T3456-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNN (Tenascin N). The antibody can be used for immunoassay techniques, such as ICC, IHC-Fr, IHC-P, WB.
See all TNN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4040
Antibody Isotype
IgG1
Application
ICC, IHC-Fr, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1.2% Sodium Acetate, 2 mg BSA
Preservative
0.01 mg Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tenascin N
Introduction
TNN (Tenascin N) is a Protein Coding gene. Diseases related to TNN include Adhesive Otitis Media and Chronic Purulent Otitis Media. Among its related pathways are ECM proteoglycans and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to TNN include identical protein binding and integrin binding. An important paralog of TNN is TNC.
Entrez Gene ID
63923
UniProt ID
Q9UQP3
Alternative Names
Tenascin N; Tenascin-W; TN-N; TN-W; Tenascin-N; TNW
Function
Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022).
Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity).
During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity).
In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).
Biological Process
Biological Process axonogenesis Source:Ensembl
Biological Process cell-matrix adhesion Source:GO_Central1 Publication
Biological Process dendrite self-avoidance Source:UniProtKB1 Publication
Biological Process negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation Source:UniProtKB
Biological Process negative regulation of neuron migration Source:UniProtKB1 Publication
Biological Process negative regulation of osteoblast differentiation Source:UniProtKB
Biological Process negative regulation of osteoblast proliferation Source:UniProtKB
Biological Process neuron projection extension Source:GO_Central1 Publication
Biological Process osteoblast development Source:UniProtKB
Biological Process positive regulation of neuron projection development Source:Ensembl
Biological Process positive regulation of sprouting angiogenesis Source:ComplexPortal1 Publication
Biological Process regulation of bone development Source:Ensembl
Biological Process regulation of cell adhesion Source:ComplexPortal1 Publication
Biological Process regulation of cell migration Source:ComplexPortal1 Publication
Biological Process regulation of smooth muscle tissue development Source:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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