TSPO

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.

translocator protein

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity).

Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).

Adrenal gland development Source: Ensembl
Aging Source: Ensembl
Anion transport Source: HGNC-UCL
Behavioral response to pain Source: Ensembl
C21-steroid hormone biosynthetic process Source: Reactome
Cellular hypotonic response Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Cellular response to zinc ion Source: Ensembl
Chloride transport Source: Ensembl
Contact inhibition Source: Ensembl
Glial cell migration Source: Ensembl
Heme biosynthetic process Source: HGNC-UCL
Lipid transport Source: UniProtKB-KW
Maintenance of protein location in mitochondrion Source: Ensembl
Negative regulation of ATP metabolic process Source: Ensembl
Negative regulation of autophagy of mitochondrion Source: Ensembl
Negative regulation of glial cell proliferation Source: Ensembl
Negative regulation of nitric oxide biosynthetic process Source: Ensembl
Negative regulation of protein ubiquitination Source: Ensembl
Negative regulation of tumor necrosis factor production Source: Ensembl
Peripheral nervous system axon regeneration Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of calcium ion transport Source: Ensembl
Positive regulation of glial cell proliferation Source: Ensembl
Positive regulation of mitochondrial depolarization Source: Ensembl
Positive regulation of necrotic cell death Source: Ensembl
Positive regulation of reactive oxygen species metabolic process Source: Ensembl
Protein targeting to mitochondrion Source: ProtInc
Regulation of cell population proliferation Source: HGNC-UCL
Regulation of cholesterol transport Source: HGNC-UCL
Regulation of steroid biosynthetic process Source: Ensembl
Response to drug Source: Ensembl
Response to manganese ion Source: Ensembl
Response to progesterone Source: Ensembl
Response to testosterone Source: Ensembl
Response to vitamin B1 Source: Ensembl
Steroid metabolic process Source: HGNC-UCL

Mitochondrion membrane

Mitochondrial intermembrane: 2-5 aa
Helical: 6-26 aa
Cytoplasmic: 27-46 aa
Helical: 47-67 aa
Mitochondrial intermembrane: 68-79 aa
Helical: 80-100 aa
Cytoplasmic: 101-105 aa
Helical: 106-126 aa
Mitochondrial intermembrane: 127-134 aa
Helical: 135-155 aa
Cytoplasmic: 156-169 aa