TULP3

TULP3 is a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. TULP3 binds to phosphoinositides in the plasma membrane via its C-terminal region and probably plays a role as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. TULP3 plays an important role in neuronal development and function.

Full Name

Tubby Like Protein 3

Function

Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes.

Biological Process

Biological Process anterior/posterior pattern specification Source:Ensembl
Biological Process bone development Source:Ensembl
Biological Process brain development Source:Ensembl
Biological Process bronchus morphogenesis Source:Ensembl
Biological Process central nervous system neuron differentiation Source:Ensembl
Biological Process embryonic camera-type eye development Source:Ensembl
Biological Process embryonic digit morphogenesis Source:Ensembl
Biological Process embryonic neurocranium morphogenesis Source:Ensembl
Biological Process G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process ganglion development Source:Ensembl
Biological Process negative regulation of smoothened signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source:Ensembl
Biological Process negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning Source:Ensembl
Biological Process neural tube closure Source:Ensembl
Biological Process protein localization to cilium Source:MGI1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source:Ensembl

Cellular Location

Nucleus
Cell membrane
Cell projection, cilium
Cytoplasm
Secreted
Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).
Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha.