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Mouse Anti-TULP3 Recombinant Antibody (CBYJT-5380) (CBMAB-T4981-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TULP3 (Tubby Like Protein 3). The antibody can be used for immunoassay techniques, such as IF, IHC-P, WB.
See all TULP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5380
Antibody Isotype
IgG1
Application
IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tubby Like Protein 3
Introduction
TULP3 is a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. TULP3 binds to phosphoinositides in the plasma membrane via its C-terminal region and probably plays a role as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. TULP3 plays an important role in neuronal development and function.
Entrez Gene ID
7289
UniProt ID
O75386
Alternative Names
Tubby Like Protein 3; TUBL3; Tubby-Related Protein 3; Tubby-Like Protein 3
Function
Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes.
Biological Process
Biological Process anterior/posterior pattern specification Source:Ensembl
Biological Process bone development Source:Ensembl
Biological Process brain development Source:Ensembl
Biological Process bronchus morphogenesis Source:Ensembl
Biological Process central nervous system neuron differentiation Source:Ensembl
Biological Process embryonic camera-type eye development Source:Ensembl
Biological Process embryonic digit morphogenesis Source:Ensembl
Biological Process embryonic neurocranium morphogenesis Source:Ensembl
Biological Process G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process ganglion development Source:Ensembl
Biological Process negative regulation of smoothened signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source:Ensembl
Biological Process negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning Source:Ensembl
Biological Process neural tube closure Source:Ensembl
Biological Process protein localization to cilium Source:MGI1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source:Ensembl
Cellular Location
Nucleus
Cell membrane
Cell projection, cilium
Cytoplasm
Secreted
Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).
Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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