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UBE2I

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Ubiquitin Conjugating Enzyme E2 I
Function
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705).
Biological Process
Biological Process cell division Source:UniProtKB-KW
Biological Process chromosome segregation Source:UniProtKB-KW
Biological Process mitotic nuclear membrane reassembly Source:Reactome
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process nuclear export Source:ComplexPortal1 Publication
Biological Process positive regulation of cell migration Source:BHF-UCL1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:Ensembl
Biological Process positive regulation of SUMO transferase activity Source:BHF-UCL1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein sumoylation Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:ProtInc1 Publication
Cellular Location
Nucleus
Cytoplasm
Cytoplasm, perinuclear region
Mainly nuclear (By similarity).
In spermatocytes, localizes in synaptonemal complexes (PubMed:8610150).
Recruited by BCL11A into the nuclear body (By similarity).
PTM
Phosphorylation at Ser-71 significantly enhances SUMOylation activity.

Anti-UBE2I antibodies

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Target: UBE2I
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF463
Application*: ELISA, WB
Target: UBE2I
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: CBFYU-114
Application*: E, F, IF, IH, P, WB
Target: UBE2I
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 67AT1273.95.90
Application*: E, WB
Target: UBE2I
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBFYU-116
Application*: E, WB, IH
Target: UBE2I
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Chicken, Dog, Mouse, Rat
Clone: CBFYU-117
Application*: WB, IF, IH
Target: UBE2I
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYU-118
Application*: WB, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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